From his Commentary on Genesis

10. And Jacob went out. In the course of this history we must especially observe, how the Lord preserved his own Church in the person of one man. For Isaac, on account of his age, lay like a dry trunk; and although the living root of piety was concealed within his breast, yet no hope of further offspring remained in his exhausted and barren old age. Esau, like a green and flourishing branch, had much of show and splendour, but his vigour was only momentary. Jacob, as a severed twig, was removed into a far distant land; not that, being ingrafted or planted there, he should acquire strength and greatness, but that, being moistened with the dew of heaven, he might put forth his shoots as into the air itself. For the Lord wonderfully nourishes him, and supplies him with strength, until he shall bring him back again to his father’s house. Meanwhile, let the reader diligently observe, that while he who was blessed by God is cast into exile; occasion of glorying was given to the reprobate Esau, who was left in the possession of everything, so that he might securely reign without a rival. Let us not, then, be disturbed, if at any time the wicked sound their triumphs, as having gained their wishes, while we are oppressed.

Calvin, J., & King, J. (2010). Vol. 2: Commentary on the First Book of Moses Called Genesis (110–111). Bellingham, WA: Logos Bible Software.